The US is 1/30 of the world population and 1/4 of its market. That makes it a desirable market, especially if you sell things like ridiculously over priced athletic shoes.
But it isn’t an essential market. A nice lucrative market, but not truly essential on a global scale.
If the US locks itself off from the rest of the world, eventually, with much pain, the rest of the world will reconfigure its trade to work around the United States.
There are numerous historical examples of countries that walled themselves off behind trade barriers. It has never ended well for the countries in question.
One wonders who will be America’s Commodore Perry.